Bioactive procyanidins from dietary sources: The relationship between bioactivity and polymerization degree

Ano: 2021

Trends in Food Science & Technology, Volume 111, 2021, Pages 114-127.


Autores/as: Haixia Yang, Xingxia Tuo, Lingbo Wang, Rosa Tundis, Maria P. Portillo, Jesus Simal-Gandara, Yan Yu, Liang Zou, Jianbo Xiao, Jianjun Deng.



Procyanidins, commonly found in plant natural sources, are polymerized forms of flavanols, which are a subclass of flavonoids. They have been reported to exhibit broad benefits to human health and used in the prevention of cancers, cardiovascular diseases, diabetes, etc. Bioactivities of procyanidins depend on many factors including the structures of procyanidins. Differences in composition of the monomers and degree of polymerization (DP) contribute to the variation in procyanidins.

Scope and approach

The basic structures and natural sources of procyanidins have been summarized in detail. Importantly, the structure-activity relationships of procyanidins, especially the relationship between degrees of polymerization and their antioxidant, anticancer, antidiabetic, anti-obesity, and cardioprotective effects as well as their potential mechanisms have been reviewed in detail. Additionally, current challenges in the studies of procyanidins have been discussed.

Key findings and conclusions

Procyanidins are structurally diverse compounds and can be classified as monomeric, oligomeric, or polymeric variants depending on the DP, which plays a role in manifesting various effects that are associated with human health. The diversity and complexity of these chemical compounds and the difficulties encountered in the isolation of plant procyanidins continue to be major challenges. A better understanding of this information may promote the use of procyanidins in improving human health.

Jesús Simal Gándara

Tipo de publicación:
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